Neoplasms evoked in male Sprague-Dawley rat by pulse doses of 7,12-dimethylbenz(a)anthracene.
نویسندگان
چکیده
In male rats of the Sprague-Dawley strain a single pulse dose of 7,12-dimethylbenz(a)anthracene elicited a few mammary and sebaceous gland carcinomas but leukemia was not observed. Multiple pulse doses enhanced the yields of these tumors and, in addition, evoked leukemia in rather high incidence. The induced mammary cancers of male rats did not regress after orchiectomy and hypophysectomy; hence they were hor mone-independent.
منابع مشابه
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عنوان ژورنال:
- Cancer research
دوره 26 11 شماره
صفحات -
تاریخ انتشار 1966